Sculptra vs. Hyperdilute Radiesse: Which Biostimulant Is Right for You?
At The Face Lab, we’re all about treatments that work with your body, not just on it. If you’re exploring more regenerative options for facial rejuvenation beyond traditional hyaluronic acid fillers, you’ve likely come across Sculptra and Radiesse. While both are biostimulant injectables—designed to stimulate your own natural collagen—they work differently and are tailored for different goals.
Let’s break down the differences between Sculptra and Hyperdilute Radiesse, so you can feel confident about choosing the treatment that aligns best with your skin goals.
What Are Biostimulants, and Why Choose Them?
Biostimulants are not your typical fillers. Unlike HA fillers, which simply add temporary volume, biostimulants trigger your body to produce collagen, offering results that evolve naturally over time. If you're looking for subtle rejuvenation, longer-lasting outcomes, and treatments that support your skin's internal architecture, biostimulants like Sculptra and hyperdilute Radiesse might be your perfect match.
The Breakdown: Sculptra vs. Hyperdilute Radiesse
1. Composition + Mechanism of Action
Sculptra (Poly-L-lactic Acid)
- Composed of PLLA, a synthetic, biodegradable substance.
- Works by stimulating collagen deep within the dermis.
- No instant volume—results develop gradually over weeks to months.
- Ideal for global volume restoration and natural rejuvenation.
Radiesse (Calcium Hydroxylapatite)
- Made from CaHA microspheres suspended in a gel.
- Offers immediate volume while also kickstarting collagen production.
- When hyperdiluted, Radiesse becomes more spreadable, perfect for skin tightening, texture improvement, and mild volume support.
- Think of it as both a volumizer and a collagen-booster depending on how it’s used.
Treatment Areas
Sculptra is great for:
- Cheeks and temples (think: lifting and restoring contour)
- Jawline refinement
- Facial hollowness from aging, weight loss, or illness
- Chest and body areas when used off-label (we’ll guide you through what’s safe and effective)
Hyperdilute Radiesse shines in:
- Lower face: smile lines, marionette lines, jawline
- Neck and décolletage: for tightening and texture
- Hands: for volume and skin quality
- Arms, thighs, and buttocks (off-label) to improve crepiness and firmness
Results Timeline + Longevity
Sculptra
- Collagen-building takes time—expect to see results gradually over 3–6 months.
- Long-lasting: up to 2+ years with proper treatment.
- Perfect if you’re after a slow, steady, and natural-looking transformation.
Radiesse (Hyperdiluted)
- Delivers instant volume
when used undiluted.
- When hyperdiluted, it improves skin texture and firmness over time—results can last 12–18 months.
- Best for those who want a visible “glow-up” sooner, while still benefiting from longer-term collagen production.
What Does the Treatment Process Look Like?
Sculptra
- Typically done in a series of 2–3 sessions, spaced 4–8 weeks apart.
- Minimal downtime—expect mild swelling or bruising post-injection.
- Full results develop over time as collagen builds.
Hyperdilute Radiesse
- Often requires 1–2 sessions depending on the area and desired result.
- You’ll see some instant improvement, especially with undiluted Radiesse, followed by ongoing skin enhancement.
- Low downtime, with results that build and refine over weeks.
Who’s a Good Candidate?
At The Face Lab, we personalize every treatment plan based on your anatomy, skin health, and goals—but here are some general guidelines:
Sculptra may be right for you if you:
- Have experienced significant facial volume loss
- Are looking for subtle, long-term improvement
- Prefer results that appear naturally over time
Hyperdilute Radiesse might be ideal if you:
- Want immediate skin rejuvenation with a side of collagen-building, especially in the neck and hands
- Are targeting skin laxity or texture issues
- Are looking for a more lifted, smoother look without the “overfilled” appearance
Final Thoughts: Which One Should You Choose?
Both Sculptra and Hyperdilute Radiesse offer incredible skin-regenerating benefits—but the best option depends on your goals, timeline, and what kind of transformation you’re envisioning.
Still not sure which biostimulant is best for you? Book a comprehensive consultation where we assess your skin, discuss your goals, and curate a plan that feels right for you.



